Following oral administration lacidipine fast but slightly absorbed from the gastrointestinal tract and is extensively metabolized “first pass” through the liver. Its absolute bioavailability of approximately 10%. The maximum concentration of lacidipine in the blood plasma is reached after 30-150 minutes. Lacidipine has a very high (over 95%) the ability to bind to plasma proteins. Primarily testosterone enanthate vs propionate metabolized in the liver with the formation of 4 main metabolites have negligible pharmacological activity. Approximately 70% of the dose is excreted lacidipine adopted in the form of metabolites in the faeces and the remainder of the dose – in the form of metabolites in the urine. The half-life ranged from 13 to 19 hours.
Arterial hypertension (as monotherapy or in combination with other drugs: beta-blockers, diuretics or angiotensin converting enzyme (ACE) inhibitors.
Hypersensitivity to the components of the aortic and subaortic stenosis, acute myocardial infarction (within 1 month after acute myocardial infarction), pregnancy, lactation, age 18 years (effectiveness and safety have been established).
Be wary of violation of intracardiac conduction, low cardiac output, unstable angina, abnormal liver function, in congenital and acquired (documented) prolongation of the interval, while the use of drugs that prolong the interval.
It is recommended to take the drug at the same time, preferably in the morning without food.
If necessary, the dose may be increased to 4 mg / day and sometimes even (if necessary) to 6 mg per day after the time required to achieve a therapeutic effect. Typically, this period is 3-4 weeks.
In elderly patients and patients with impaired hepatic function dose adjustment is required.
Since testosterone enanthate vs propionater is not excreted by the kidneys, the dose correction Nazis with impaired renal function is not required.
On the part of the central nervous system: dizziness, headache, weakness, mood changes; rarely – fatigue, cramps.
Cardio-vascular system: tachycardia, palpitations, increased angina attacks (more frequently in patients with coronary heart disease at the beginning of treatment), pain in the chest.
From the digestive system: nausea, constipation; long-term use – gingival hyperplasia, increased alkaline phosphatase activity. From the urinary system: peripheral edema; rarely – polyuria. Allergic reactions: skin rash, “tides” of blood to the skin.
Symptoms: marked reduction of blood pressure, tachycardia (related to the long-term expansion of peripheral blood vessels), the AV conduction, bradycardia, confusion, stupor, nausea, vomiting, metabolic acidosis, hyperglycemia. Treatment: symptomatic. No specific antidote.
INTERACTION WITH OTHER DRUGS
Compatible with beta-blockers, diuretics, digoxin and warfarin.
Eliminates the inhibitory effect testosterone enanthate vs propionate of cyclosporin on glomerular filtration rate.
Beta-blockers, verapamil, tricyclic antidepressants, diuretics, inhibitors increase the hypotensive effect.
Cimetidine slows the metabolism in the liver, increasing lacidipine concentration in blood plasma.
Grapefruit juice reduces the bioavailability and metabolism. Sackur can not drink grapefruit juice.
The antihypertensive effect of weakening non-steroidal anti-inflammatory drugs (delay Na + and renal prostaglandin synthesis blockade) and estrogens (Na retention).
In the period of treatment must be careful when engaging in potentially hazardous activities that require high concentration and psychomotor speed reactions. During treatment, you should take the standard measures to control the functional activity of the myocardium and blood pressure. When angina attacks or worsening angina soon testosterone enanthate vs propionate after initiation of therapy Sakura, as well as in severe hypotension drug should be abolished. winidrol review