If overdose is testosterone propionate dosage necessary to gastric lavage and symptomatic therapy. There is no specific antidote.
Interaction with other drugs, laboratory and diagnostic tests
is not recommended concomitant use of terfenadine , due to higher concentrations of the latter at the same time taking macrolide antibiotics, which can lead to the development of severe ventricular arrhythmias. Although this complication was not observed in roxithromycin, and studies on human volunteers did not show any pharmacokinetic interactions or ECG changes, it is not recommended combination of roxithromycin and terfenadine.
Reception of drugs such as testosterone propionate dosage astemizole, cisapride, pimozide may lead to a lengthening interval and / or serious arrhythmias of the heart, resulting in an increase in their serum, as a result of the competitive influence of isozyme between the above mentioned drugs and macrolide antibiotics.
The interaction with warfarin, karbamazepshom, ranitidine, antacids, and oral contraceptives available.
When concomitant administration of roxithromycin with vitamin K antagonists it is recommended to monitor the prothrombin time and international normalized ratio.
Roxithromycin can replace protein bound disopyramide, leading to increased serum levels of disopyramide. Monitoring testosterone propionate dosage is recommended and, if possible, determine the level of disopyramide in serum.
When concomitantly with digoxin may increase absorption of the latter. It is recommended to monitor the electrocardiogram and serum level of the cardiac glycoside. This is a must for symptoms of overdose of cardiac glycosides.
Roxithromycin may increase the half-life of midazolam, leading to a strengthening and lengthening his actions.
In appointing the drug to patients with liver failure need special care, monitoring of liver function and dose adjustment.
In appointing the drug to patients with renal insufficiency, as well as elderly patients, the need to adjust the testosterone propionate dosage dose does not arise.