testosterone propionate

Testosterone propionate is rapidly absorbed after oral administration.  Stable than other macrolides in an acidic environment of the stomach. Eating after 15 minutes. after the drug has no effect on pharmacokinetics.

The active substance is detected in the serum within 15 minutes after administration. Maximum concentration in the blood is, on average, 6.6 mg / l is achieved in 2.2 hours after administration at a dose of 150 mg. After a single dose of 300 mg of roxithromycin average maximum blood concentration of 9.6 mg / L and reached after 1.5 hours.

Receiving drug every 12 hours, preserves effective concentrations in the blood throughout the day.

Testosterone propionatepenetrates well into many tissues and organs (including the lungs, tonsils, prostate), into cells, particularly monocytes and polymorphonuclear leukocytes by stimulating their phagocytic activity. Practically it does not penetrate the blood-brain barrier. Relationship to plasma proteins – 96%

It is metabolized in part. The half-life (T1 / 2) after a single dose is an average of 10.5 hours in children (under 13 years old.) – up to 20 hours in adults with normal renal function and liver 65% roxithromycin displayed through the intestines. Less than 0.05% of the dose is excreted in breast milk.

In severe renal insufficiency T1 / 2 – 25 h

In older patients (60-79 years) increased T1 / 2.

– infectious and inflammatory diseases caused by susceptible to malaria infections, incl .:
– infections of the upper testosterone propionate respiratory tract and LOP-organs (acute pharyngitis, tonsillitis, sinusitis);
– infections of the lower respiratory tract (pneumonia, bronchitis, , bacterial infections in chronic obstructive pulmonary disease, including those caused by atypical pathogens);
– skin and soft tissue infections;
– urogenital infections (excluding gonorrhea), including urethritis, cervicovaginitis.

– Hypersensitivity to other macrolides roxithromycin and;
– simultaneous reception of preparations of derivatives ergotamine and dihydroergotamine;
– pregnancy;
– lactation
– Children under 3 years of age or with body weight less than 30 kg

Precautions: hepatic impairment, in patients older than 65 years.

Dosing and Administration
Inside.  Should be taken before meals, drinking plenty of water.

Adults and children over 12 years (with a body weight of 40 kg.): 150 mg 2 times a day, with an interval of 12 hours is possible appointment of 300 mg once a day.

Duration of roxithromycin depends on indication for use, the severity of infection and pathogen activity. Average duration of treatment course is 5-12 days, chlamydia and mycoplasma pneumonia – 14 days, Legionella pneumonia -up to 21 days.

In elderly patients dosage and daily dosage roxithromycin is not changed.

Children from 3 to 12 years (with a body weight of at least 30 kg): the drug is prescribed, depending on body weight, type of pathogen and the severity of the infection process. The recommended dosage is 5-8 mg / kg per day in 1-2 reception, the duration of treatment is 10 days.

Patients with hepatic insufficiency, the drug is prescribed in a dose of 150 mg 1 time per day.

For patients with severe renal failure (creatinine clearance less than 15 mL / min), the recommended dose is 150 mg every 24 hours.

Side effects: Allergic testosterone propionate reactions: rash, flushing, urticaria, angioedema, bronchoconstriction, weakness; rarely – anaphylactic shock.

From the gastrointestinal tract: a slight change in taste and loss of appetite, nausea, vomiting, abdominal pain, bloating, diarrhea (rarely with blood), transient increase in activity of “liver” transaminases, cholestatic or hepatocellular acute hepatitis; in some cases, we observed symptoms of pancreatitis, increased activity of alkaline phosphatase, pseudomembranous enterocolitis.

From the nervous system: dizziness, headache, paresthesia.

Other: possible development of superinfection due to growth of non-susceptible organisms, candidiasis, fever, pigmentation of nails.

In case of overdose, the stomach is washed and symptomatic treatment. There is no specific antidote.

Interaction with other drugs
combined use of ergotamine derivatives and ergotaminopodobnymi vasoconstrictor is not allowed, because This combination may lead to development of “ergotism” limb necrosis and tissue.

When concomitantly with digoxin may increase its absorption.

Macrolide antibiotics may increase serum concentrations of terfenadine, astemizole, cisapride, pimozide while admission that can cause QT interval prolongation and / or development of severe ventricular arrhythmia (ECG monitoring is required).

Reduces the effectiveness of indirect anticoagulants.

Increases T1 / 2 of midazolam (gain and an increase in duration of action).

Increasing the concentration of theophylline in the plasma cyclosporin A (no correction dosing regimen).

Disopyramide may displace from its association with plasma proteins, resulting in an increase in its serum concentration.

Interaction with carbamazepine, ranitidine, antacids, oral contraceptives (containing estrogen-progestogen) is absent.

With the development of superinfection or pseudomembranous colitis roxithromycin should be immediately withdrawn and appropriate therapy.
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