what is testosterone propionate

The pharmacokinetics of ceftriaxone is not linear. All the main pharmacokinetic parameters based on the total concentrations of the drug, except half-life depends on dose. Absorptionmaximum plasma concentration after a single intramuscular administration of 1 g of the drug is about 81 mg / l and is achieved within 2-3 hours after what is testosterone propionate¬†administration area under curve “in the plasma concentration – time” after intravenous and intramuscular injection of the same. This means that the bioavailability of ceftriaxone after intramuscular injection is 100%. The distribution volume of distribution of ceftriaxone is 7-12 l equals. After a dose of 2.1 g of ceftriaxone well penetrates the tissues and body fluids. Within 24 hours concentration much higher than the minimum inhibitory concentration for most pathogens for more than 60 tissues and fluids (including lung, heart, biliary tract, liver, tonsils, middle ear and the nasal mucosa, bones, and spinal, pleural and synovial fluids and prostatic secretions).

After intravenous what is testosterone propionate administration of ceftriaxone rapidly penetrates into cerebrospinal fluid, where bactericidal concentrations against susceptible microorganisms stored for 24 hours. protein binding ceftriaxone is reversibly bound to albumin, and coupling degree decreases with increasing concentration, decreasing, for example, from 95% at a plasma concentration of less than 100 mg / l to 85% at a concentration of 300 mg / l. Due to lower concentrations of albumin in the tissue fluid, the proportion of free ceftriaxone it is higher than in plasma.

Penetration into individual tissues Ceftriaxone penetrates the inflamed meninges in children, including infants . 24 hours after intravenous Rocephin in doses of 50-100 mg / kg body weight (babies and infants, respectively) ceftriaxone concentration in the cerebrospinal fluid higher than 1.4 mg / l. Maximum concentration in the cerebrospinal fluid is achieved in about 4 hours after intravenous administration and is on average 18 mg / l. When the average concentration of bacterial meningitis in the cerebrospinal fluid of ceftriaxone is 17% of the plasma concentration of aseptic meningitis – 4%. In adult patients with meningitis through 2-24 hours after dosing of 50 mg / kg body weight, ceftriaxone concentration in cerebrospinal fluid many times greater than the minimum inhibitory concentration for the most common meningitis pathogens. ceftriaxone crosses the placental barrier and at low concentrations into breast milk. Metabolism ceftriaxone is not metabolised systemically and converted into inactive metabolites by the action of the intestinal flora. Excretion Total plasma clearance of ceftriaxone is 10 -22 ml / min. Renal clearance equal to 5.12 ml / min. 50-60% of ceftriaxone is excreted unchanged in the urine, and 40-50% – unchanged in the bile. The half-life of ceftriaxone in adults is about 8 hours.
In newborn children through the kidneys derived about 70% of the dose. Infants in the first 8 days of life, as well as in individuals older than 75 years half-life, on average, two or three times greater than that of young adults.
In patients with impaired renal or hepatic function The pharmacokinetics of ceftriaxone changes insignificant notes only a small increase in half-life. If broken only kidney function, increases the excretion of the bile if disturbed only by liver function, increases the excretion through the kidneys.

Indications
Infections what is testosterone propionate caused by pathogens sensitive to Rocephin: sepsis; meningitis; disseminated Lyme borreliosis (early and late stages of the disease); infections of the abdominal cavity (peritonitis, biliary tract infections and gastrointestinal tract); infections of bones, joints, soft tissue, skin and wound infections; infections in patients with weakened immune systems; kidney and urinary tract infections; respiratory tract infections, particularly pneumonia, and upper respiratory tract infections; genital infections, including gonorrhea.
Perioperative prophylaxis of infections.

Contraindications
: Hypersensitivity to cephalosporins.

Precautions
Hypersensitivity to penicillins.
Hyperbilirubinemia in neonates (especially preterm).
The period of lactation.

Pregnancy and lactation Category B Ceftriaxone crosses the placental barrier. Safety of use in pregnancy has not been established for women. Preclinical studies of reproduction revealed no embryotoxic, foetotoxic, teratogenic or other adverse effects of the drug on fertility in males and females, the process of birth, perinatal and postnatal development of the fetus. During pregnancy, especially in the first trimester, should be administered only under strict indications. In low concentrations Ceftriaxone passes into breast milk. With his appointment as a nursing mother should be careful.

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